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However, this significance was not observed in the meta-analysis of the two randomized controlled trials (RCTs) conducted exclusively in vivo

Consequently, expression of IL-2, TNF-, and IFN- was reduced, leading to impaired anti-tumor function ( 2+ influx and excessive activation of NFAT ( Conversely, studies examining the effects of methionine in the context of immune checkpoint blockade (ICB) therapies indicate a more suppressive role