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Infants & Toddlers: Motor milestone delays (delayed crawling, sitting, or walking) Colic (poor sleep or inconsolable crying) Failure to thrive (feeding difficulties) or gastrointestinal issues Hypotonia (low tone or floppy limbs) Breathing difficulties Preschool & Elementary-Aged Kids: Sensory processing disorder (sensory overload in loud or busy spaces ) Behavioral issues (emotional outbursts or shutdowns) Fatigue after normal activity Frequent infections Neurological problems (seizures, tremors, developmental regressions) Tweens & Teens: Brain fog and memory issues Anxiety, mood swings, or low energy Sleep problems (trouble sleeping or staying asleep) Poor focus, decision making or academic problems at school Frequent illness Is mitochondrial dysfunction reversible

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The end products/metabolites of ROS/RNS are stable, can accumulate to detectable concentrations, reflect specific oxidation pathways, and correlate with disease severity