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Finally, existing challenges to brain drug delivery using nanoparticles are presented, such as the accumulation of nanoparticles in the brain, which can produce neurotoxicity, and the lack of preclinical CNS disease models that can mimic the microenvironment of the human brain relatively perfectly

Hasanuzzaman M, Hossain M, Bhuyan M, Mahmud J, Nahar K, Fujita M (2018b) The role of sulfur in plant abiotic stress tolerance: molecular interactions and defense mechanisms