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TFEB and TFE3 sequestration affects the lysosomal functionality To understand the effects of TFEB and TFE3 sequestration into muHTT inclusions and due to their crucial role in the regulation of autophagy, lysosomal function and biogenesis, we evaluated the expression of genes controlled by TFEB/TFE3 and involved in the proteostasis pathways in presence of wt and muHTTs