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Vagotomy in animal studies is said to disrupt the transfer of -synuclein derived from the gut to the CNS, but human observational evidence is inconsistent, with some studies indicating no change in PD incidence and others suggesting a reduced risk following truncal vagotomy (Elfil et al., 2020)

While these findings are highly promising, the substantial heterogeneity ( I 2 = 49%) reflect more recent trial outcomes which have not shown statistically significant N-acetylcysteine and placebo differences

Its ability to activate sirtuins, enhance DNA repair, regulate metabolism, influence fat cell metabolism in preclinical models and support mitochondrial health positions it as a compelling candidate for further investigation

The number of gut microbiota-specific Th17 cells, such as those specific to Candida albicans, increases during ALD, and these cells migrate to the liver, further amplifying the inflammatory response [100]