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doi: 10.1016/bs.apcsb.2016.11.001 192 XiaoXShiXFanYWuCZhangXMinzeLet al

As stated earlier, HIF-1 subsequently binds to hypoxia response elements (HREs) present in the VEGF promoter region leading to transcriptional activation of VEGF, resulting in increased VEGF production and secretion [129] (Fig