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These drugs have demonstrated effectiveness in lowering the incidence and development of breast, colorectal, cervical, and liver cancers by inducing apoptosis, limiting angiogenesis, and blocking metastasis in vitro and in vivo models (12, 44)

Interestingly, IGF-I is somehow related to all of them (Figure3)

Future advances in single-cell sequencing, spatial transcriptomics, and spatial metabolomics will enable more precise tumor subtyping and refined diagnostic strategies, thereby unlocking greater opportunities for targeted metabolic therapies in colorectal cancer