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253,254 It is noteworthy that persistent neuroinflammation may lead to the infiltration of peripheral immune cells (such as T cells, B cells, monocytes, and neutrophils), yet the mechanisms of this infiltration and impacts on ADs disease progression remain to be studied

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The computed energy barrier for Cu(II)-catalyzed methionine oxidation is 14.3 kcal/mol significantly lower than for Zn (19.6 kcal/mol) or Fe (16.9 kcal/mol), making copper the most efficient catalyst among common metal ions