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However, most dermatological organisations including the American Academy of Dermatology and the Philippine Dermatological Society, which has monitored this trend closely given its popularity in Asia note that the long-term safety of high-dose glutathione supplementation specifically for cosmetic skin lightening has not been established

Large-scale, long-term randomized trials have been conducted, and are ongoing, to evaluate the viability of dulaglutide as a therapeutic agent for the treatment of T2DM (63)

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This reduction of NP hydration results in loss of disc height and disc bulging (Kumaresan et al., 2003)