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performed a study which not only highlighted the nephrotoxic behavior of mechlorethamine, but also investigated the protective role of melatonin and S-methylisothiouria (potent iNOS inhibitor) by taking biochemical and histological data into consideration.100 Transdermal administration of mechlorethamine 3.5mg/kg demonstrated the severe induction in TNF-, IL-1 and NO and morphological damages such as glomerulo-peritubular congestion and mild mesangiolysis

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