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3.1.2 PKM2: driven metabolic rewiring Pyruvate kinase is the rate-limiting enzyme that catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, serves as a critical metabolic and immunological node in T cell fate determination

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Topical application of Ferrostatin-1 effectively reduced the severity of psoriasis-like lesions by decreasing the levels of various pro-inflammatory cytokines

Molloy et al., 2018)