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This region-specific action is associated with its local stimulation of hormone-sensitive lipase and enhanced fatty acid oxidation, suggesting potential for site-selective metabolic modulation without systemic hormonal changes

These risks highlight the need for individualized assessments before intervention, standardized dosing and duration, and long-term safety monitoring to ensure clinical applicability and minimize potential harms

Furthermore, several studies were conducted on various classes and isoforms of GSTs to obtain informations about their association with increased risk for the development of the disease 47,50

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