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Received: Revised: Accepted: Published: Version of record: Issue date: DOI:

In parallel, Ca 2+ dysregulation, endoplasmic reticulum stress and mitochondrial dysfunction further exacerbate astrocytic impairment 114

2025;122(24):e2503574122

In another study, researchers investigated the effect of high iron content on the articular chondrocytes isolated from Hfe KO mice and compared the results with the results obtained by studying wild-type mice (Simo et al., 2019)