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After one week of acclimatization, mice were randomly assigned to experimental groups

Conclusion: Linafexor (CS0159), a pulse FXR ligand with a short half-life, demonstrated significant efficacy in treating NASH by modulating the metabolic cycle of bile acids in accordance with circadian rhythms

Interestingly, mice fed a high-fat diet exhibited lower expression of ZIP7, consistent with the onset of insulin resistance in muscle (266) ( Figure 3B )