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The addition of warmth toward the continuous delivery of O 2 possibly increases vasodilation, subsequently maintaining the optimal humidification and hydration level at the ulcer site

Results clearly showed that the c-met-binding of LASSS-treated HGF ( blue bars 4 ) was more than double that of the control level of HGF ( gray bars 3 , with the wash-out step)

This process is thought to be mediated by Nrf2 activation and subsequent antioxidant gene expression, which reduces the level of plasma MDA and helps in restoring redox balance

doi: 10.1371/journal.pone.0123088 4 Garcia-RomoGSCaielliSVegaBConnollyJAllantazFXuZet al