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In terms of clinical application, targeting the MG metabolic pathway provides a dual therapeutic strategy: first, for tumors with high glycolytic activity, by inhibiting GLO1 activity to selectively elevate MG levels in cancer cells and enhance the sensitivity of tumor cells to therapy

4 In humans, DR may be associated with severe side effects and elevated risk of malnutrition, especially with regard to protein and micronutrient requirements

Sims ST, Kerksick CM, Smith-Ryan AE, Janse De Jonge XAK, Hirsch KR, Arent SM, Hewlings SJ, Kleiner SM, Bustillo E, Tartar JL, Starratt VG, Kreider RB, Greenwalt C, Rentera LI, Ormsbee MJ, VanDusseldorp TA, Campbell BI, Kalman DS, Antonio J

Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies