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This damage to the skin barrier at lesion sites intensifies the inflammatory response and worsens the severity of acne lesions

Generally, PD shows major pathology through dopaminergic neuron degeneration in the substantia nigra, causing an approximately 80% decline of dopamine levels in the striatum ( Glutamate represents the dominant excitatory neurotransmitter across central nervous system pathways

The liver is the primary organ responsible for iron storage and regulation, making it highly susceptible to iron overload-induced injury [4]

Deficiency might stem from genetics or selenium lacks, amplifying age-related declines