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Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

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Key areas of interest include: Cell proliferation and differentiation in multiple tissue types Muscle biology , including satellite cell behavior and myostatin-related pathways Metabolic signaling , particularly IGF-1R and insulin receptor cross-talk Tissue maintenance and repair models in long-term aging and glucocorticoid-exposure paradigms By offering a prolonged IGF-1like signal, IGF-1 LR3 enables researchers to investigate sustained pathway activation and long-term cellular responses in a more controlled way than with short-lived native IGF-1

3 Results 3.1 Untargeted metabolomic profiling of serum reveals potential biomarkers for pneumonia To systematically elucidate metabolic reprogramming in pneumonia, we established two murine models of pneumonia using LPS and papain