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Growing evidence indicate that surgical interventions and general anesthesia can disrupt gut microbiota homeostasis, compromise both intestinal mucosal barrier integrity and BBB function, thereby facilitating bacterial translocation and metabolite dissemination into systemic circulation (Minerbi and Shen, 2022)

Morin hydrate (100 mg/kg) protects against this renohepatic damage through antioxidant and anti-inflammatory mechanisms, restoring organ function, reducing oxidative stress, and preventing histological damage

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NSAIDs presently are the most widely used drugs in medicine and their annual sales in the world are more than 6billion dollars