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Examples that a sulfenic acid intermediate is formed during redox regulation are become known for c-Jun, Fos, nuclear factor 1, nuclear factor-B (NF-B), GAPDH, and PTPs and up to date there are 2200 experimentally verified S -glutathionylated peptides from 169 research articles (Chen et al., 2014)

Indeed, patients with SOD1 mutations, C9ORF72 expansions, and sporadic ALS exhibit distinct glucose metabolic profiles, potentially reflecting different pathological involvement across cortical regions 27,28

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