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There are numerous potential therapeutic targets, such as the development of targeted inhibitors of ion channels (sodium channels, potassium channels, calcium channels, etc.) and glutamate receptors, to reduce the neuronal excitotoxicity caused by excessive glutamate release (52, 53)

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Valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable

Similar to the positive-regulated genes, our qPCR validation on negative-regulated genes (Figure 2C) were also matched well with the transcriptomic data (Figure 2A