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In activated HSC cultures (passage 37 LX-2 line or primary rat HSC activated by plastic-culture for 7 days), ipamorelin reduces -SMA (ACTA2) expression by western blot and immunofluorescence, attenuates COL1A1 and COL1A2 mRNA transcription as assessed by qPCR, and reduces Sircol-measurable secreted collagen in conditioned media

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Daly DD, Yoss RE

At six weeks postimplantation, the authors documented that eMSC-based nanomesh substantially increased the expression of genes associated with ECM synthesis and cell adhesion, such as Tgfb1 and Tgfbr1, and other genes related to angiogenesis, such as CXCL12 (Darzi et al