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The role of adipogenesis in obesity-associated IR and T2DM The adipose tissue is a dynamic part of the endocrine system that plays a crucial role in maintaining energy balance and nutritional homeostasis [37]

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Polyunsaturated fatty acids (PUFAs), except for erucic acid, are more potent stimulators of PPAR than monounsaturated fatty acids (MUFAs) and saturated fatty acids [122, 123, 124, 125, 126] ( Figure 2 )

These factors suggest starting slightly higher than the minimum effective clinical dose to account for real-world variability