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For women, this means CoQ10 (often 100-200 mg as a starting dose), myo-inositol (2-4 g in PCOS-inclusive formulations), additional vitamin E and selenium for ovarian antioxidant support, and active folate (methylfolate rather than folic acid), which stays biologically active regardless of your MTHFR genotype, relevant because the C677T variant reduces enzyme activity by roughly 35% in heterozygotes and 70% in homozygotes, 11 and around 30-40% of people of European ancestry carry one or two copies of the variant

Hauser NS, Manoli I, Graf JC, Sloan J, Venditti CP (2011) Variable dietary management of methylmalonic acidemia: metabolic and energetic correlations

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