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Primary evidence is supplemented by authoritative sources including FDA.gov, NIH.gov, MayoClinic.org, and ClevelandClinic.org due to limited recent peer-reviewed publications on FDA status and long-term safety for this specific query

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389 Natural compounds such as resveratrol, which induces autophagy through SIRT1 activation, 390 and spermidine, a polyamine that enhances autophagic flux, further demonstrate the therapeutic potential of autophagy induction in NDDs