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In the absence of oxygen, photochemical reactions of the polymer lead to the formation of polyenic -(CH=CH-) n - sequences and thus to the discoloration (yellowing) of the polymer

Ultrastructural analysis by transmission electron microscopy further suggested that in the TB-500 group, the newly formed collagen fibrils tended to be thicker, with diameters extending up to around 87 nm, compared to a maximum of 62 nm in control tissue

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