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Carotenoid concentrations in your skin plummet, stripping away natural protection against oxidative damage

10.3389/neuro.07.003.2009 76 FlemingS

This increased ROS production is exacerbated by activation of the NADPH oxidase system and increased NADPH levels through the hexose monophosphate shunt, which supports ROS generation [144]

Furthermore, SFN may activate Nrf2 by initiating the transcription of trigger receptor expressed on myeloid cells-2 (TREM2) in the medial PFC (mPFC), increasing the expression of the M2 microglial marker arginase 1 (ARG1), which may alleviate depressive phenotypes through its anti-inflammatory and neuroprotective functions (He et al., 2022)