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In metazoans the catalytic direction is irreversible, thereby preventing the use of Cys for Met production [129, 135]

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doi: 10.1136/ard.45.10.827 50 FischerRTrudgianDCWrightCThomasGBradburyLABrownMAet al

As such, these genes may have been inherited from ancestral cyanobacteria inhabiting a metal-rich environment (Oremland et al., 2009), be used to detoxify other metals such as antimony (Nagy et al., 2014), or cope with reactive oxygen species and oxidative stress (Latifi et al., 2009