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Minimal side effects were seen, such as temporary erythema, edema, and pain at the injection site

This is due to its association with end-stage kidney disease (ESKD) as well as increased cardiovascular morbidity and mortality (108, 109)

Moreover, metallic NPs (particularly silver and gold) are often associated with antimicrobial activity, which may raise concerns about promoting microbial resistance or biofilm-associated tolerance [149]