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Each of these molecules exerts distinct effects on cellular function, both locally and distally, through individual molecular targets [12, 13]

A recent editorial in Arthroscopy , a top journal in the field, highlighted this mismatch directly

Since the very beginning, Roberts stomach cytoprotection/adaptive cytoprotection/organoprotection has been in the focus on the demonstration of the particular beneficial effect of the cytoprotectants, using prostaglandins as the prototype, but also other standard cytoprotectants