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The reaction catalyzed by GPATase, being the first committed step of the pathway, represents the primary control point

Adequate protein intake ensures sufficient amino acid availability

DTCs can reduce cytotoxicity and prevent DNA damage and cell death through increasing the activity of aldehyde dehydrogenase (ALDH) and overcoming the accumulation of toxic intermediates, aldehydes (98)

Moreover, HAs strong hydrophilicity, while advantageous for tissue hydration and lubrication, often results in weak mechanical strength, poor structural stability, and rapid clearance, limiting its use in load-bearing tissues or long-term applications