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Studies have reported that disturbances in iron metabolism, encompassing both iron deficiency and iron overload, may result in a dynamic imbalance between bone resorption and formation, contributing to OP [20, 71]

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This can be attributed not only to insufficient knowledge and action in the field of prevention but also to the fact that most kidney diseases are asymptomatic during their initial stages

Current therapeutic options for mild TAO include observation, patient education, lifestyle changes (i.e., smoking cessation, salt restriction, sun protection) and ocular surface lubrication