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In the lamina propria, some GIP glutamines are deamidated to glutamate by transglutaminase 2 (TG2) (Zhuang and Khosla, 2020) and subsequently bind to antigen-presenting cells (APCs)dendritic cells, macrophages, and B cells (Wei et al, 2020)previously activated by pro-inflammatory cytokines such as interleukin (IL)-15 and type-1 interferons (IFNs)

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This model is employed to examine the biological impacts of aerosol compounds, including cigarette smoke (CS), as the respiratory epithelium acts as a barrier safeguarding the lungs from toxins

HY-12678, MedChemExpress, 7% DMSO (Sigma), 10% Tween 80 (Sigma) in sterile H 2 O) for 15 days and controls with equivalent volume of vehicle