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Because tRFs harbor repetitive sequence motifs inherited from their parental tRNAs, changes can be detected in an entire family of closely related transcripts, albeit of different origins and types, produced by different endonucleases 20,21,27 , and originating from either nuclear or mitochondrial genomes

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doi: 10.1016/j.idc.2021.03.001, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Seleem D., Benso B., Noguti J., Pardi V., Murata R

The sample of this study was female Balb/c mice aged 23 months, divided into 2 groups (5 of each group)