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Reactive oxygen species or oxygen metabolites like superoxide dismutase and hydrogen peroxide, are generated in all cells and can damage lipids, DNA, and proteins

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This guide breaks down every dose of both compounds, maps them against each other week by week, and shows you exactly what the clinical trial data says about outcomes at each level

In line with its improved degradation potency, ZZ2-SO 2 H ( 6 ) promotes more robust BRD4 BD1 ubiquitylation and mediates a more stable ternary complex manifested by ~4-fold higher affinity of the degraderBRD4 BD1 composite surface toward YPEL5 (Extended Data Fig