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In addition, widespread application of nuclear technology may increase accidental or occupational radiation exposure, such as nuclear accidents, terrorist attacks, etc, which finally leads to radiation-induced injury or even mortality ( Ionizing radiation induces cellular damage through direct deposition of energy and indirect oxidative damage caused by excessive reactive oxygen species (ROS), which is the main toxic effects of ionizing radiation ( Functional Significance of BH4 5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for multiple enzymes, including three aromatic amino acid hydroxylases (phenylalanine hydroxylase, tyrosine hydroxylase and tryptophan hydroxylase) and nitric oxide synthases (NOSs) ( Figure 1 )

J Biol Chem 283:83748383 Khan MN, Mohammad F, Mobin M, Saqib MA (2014) Tolerance of plants to abiotic stress: a role of nitric oxide and calcium

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Lagoda, G., Sezen, S