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1 2 Neurochemical Research

ROS generated from dysfunctional mitochondria act as signaling molecules that activate various transcription factors, such as NF-B, ATF2, and HIF-1, to activate the stress response, inflammation, and metabolic adaptation

The overall lower total organic content for the FA-conjugated material (30%) compared with the non-conjugated drug-loaded SBA-15 (50%) implies that conjugation reduced the amount of physically adsorbed (free) drug for example by replacing weakly adsorbed drug with covalently tethered folic-aciddrug species or by additional washing steps removing unbound drug