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GSH levels decrease with age and due to certain disease states e.g Type 2 Diabetes Mellitus, cardiovascular disease.(2) Oral NAC increases GSH levels by providing the liver with an increased supply of cysteine promoting an increase in GSH synthesis, and therefore reduce oxidative stress

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Upon activation by ligand binding, AhR is released from the translocation inhibitory complex (formed by chaperone proteins HSP90 and XAP2) which reveals AhRs nuclear localization signal (NLS)