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JiaJDouPGaoMKongXLiCLiuZet alAssessment of causal direction between gut microbiotadependent metabolites and cardiometabolic health: a bidirectional Mendelian randomization analysis

Health and sports officials are concerned about the increasing number of athletes utilizing ergogenic aids and nutritional supplements

For instance, through DNMT3B, methylglyoxal (MG), a byproduct of glycolysis, can cause hypermethylation of tumor suppressor genes in breast cancer [55], demonstrating that metabolites act as epigenetic messengers. It is unclear, nevertheless, whether MG controls DNMTs in TC (especially the BRAF V600E mutant subtype) via a comparable mechanism, causing essential tumor suppressor genes, such as RASSF1A or PTEN, to become hypermethylated and promoting dedifferentiation and treatment resistance