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Cu complexes may work as DNA topoisomerase inhibitors of antiproliferative anticancer activity, known as DNA-damaging drugs or poisons that arrest cancer cells in G2/M [28]

On the other hand, some treatments, like RevA, BB0689, rOspA , OspA-Ferritin, lipidated rOspA, CspZ-VLP, and OspA mRNA-LMP, did not show any significant effects