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Structural characterization of Hericium coralloides polysaccharide and its neuroprotective function in Alzheimer's disease

Oxidative stress arises from an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system, disrupting redox homeostasis and promoting damaging effects on the structural and functional aspects of the cell [9]

Therefore, we optimized our search strategy by categorizing the botanical drugs into metabolites such as flavonoids, polyphenols, terpenoids, alkaloids, saponins, and anthraquinones, and combining these with more specific keywords like ALD, alcohol-related liver disease, alcoholic liver disease, oxidative stress, and ROS to improve the search accuracy

found that Tan IIA (100 M) can reduce MMP-9 activity by inhibiting ERK1/2/AP-1 and Akt/NF-B signaling pathways, thereby inhibiting HASMC migration (Jin et al., 2008)