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Description

Pharmacokinetics: administered as eye drops, or topically to the skin does not readily cross the blood brain barrier due to a low lipid solubility

10.1073/pnas.97.13.7551 Proc

4.4.3 Nose-to-brain delivery Intranasal drug delivery has been recognized as a promising non-invasive strategy for CNS targeting in AD because it may enable nose-to-brain transport through olfactory and trigeminal pathways