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While these strategies are mostly preclinical, clinical translation of these strategies is limited due to off-target effects on other immune cells residing in the TME that rely on glycolysis as an energy source

Profound hypokalaemia resulting in maternal cardiac arrest: a catastrophic complication of hyperemesis gravidarum

(2016) 5:e44

They have many beneficial traits that make them appealing, such as high stability for long-term storage, easy synthesis for efficient production, and better drug absorption than traditional formulations [164, 165]