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[PMID: 3030831] [17] van Sande J, Cochaux P, Dumont JE

doi: 10.1080/01443615.2022.2144171

Additionally, fibroblasts can also respond directly to IL-4 and IL-13 signaling, which stimulates their transformation into myofibroblasts (36, 41)

In typical ERK1/2 pathways, ligand-induced activation of receptor tyrosine kinases (RTKs) at the plasma membrane activates and recruits the small GTPase RAS in its GTP-bound form, which then triggers dimerization and activation of MAP3K RAF to initiate a downstream phosphorylation cascade for sequential activation of MAP2K MEK and MAPK ERK (Lavoie and Therrien 2015)