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Targeted delivery enables precise accumulation of immunotherapeutic agents at tumor sites through passive enhanced permeability and retention (EPR) effects or active targeting ligands such as antibodies, peptides, or polysaccharides, thereby minimizing systemic exposure, reducing off-target toxicity, and maximizing antigen and adjuvant availability to tumor resident APCs

TNF-alpha is a cytokine, or protein, within your body that prompts the creation of inflammation