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Mild, transient effects during the first two weeks typically do not require intervention beyond patience

Weeks 12-16+: optimization and maintenance Beyond the 12-week mark, the rate of change typically slows as the body reaches a new equilibrium

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

Hematocrit, reticulocyte count, vitamin B 12 , folate and iron levels should be obtained prior to treatment