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Detailed human pharmacokinetic data isnt available

Ranking Antidepressants by Metabolic Risk: The Complete Picture Based on the current evidence, heres a comprehensive ranking of antidepressants from most to least metabolically problematic: Highest Metabolic Risk: Avoid in Patients with Metabolic Concerns Tricyclic Antidepressants (TCAs): Amitriptyline (Elavil) Substantial weight gain, often 10-15+ pounds Strong H1 antihistamine effects Increased diabetes risk (RR up to 1.39 in meta-analyses) Worsens insulin resistance Also causes sedation, dry mouth, constipation, cardiac effects Clinical use: Rarely used first-line now

Lack of rest increases oxidative stress, forcing your body to burn through its glutathione faster

10.1186/s40168-016-0176-z 290 ZhangX.DeekeS