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Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5

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Complementary mechanistic evidence has emerged from neurodegenerative research: In Parkinson's disease (PD) models characterized by substantia nigra dopaminergic neuron loss, Trx1 exerts ferroptosis inhibition via the modulation of GPX4 activity and glutathione (GSH) (65)

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