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The clinical diagnosis of PD depends mainly on patients medical history and physical examination

The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.[9] So, the predominant mechanism of hyper pigmentation in vitamin B12 is hypothesised as 1) Deficiency of vitminB12 decreases the level of reduced glutathione, which activate tyrosinase and thus leads to transfer to melanosomes

After 14 days of administration of different natural products or vehicle, blood samples were collected for hematological and serum biochemical analyses

The GIP receptor activation in adipose tissue may provide additional benefits for fat mobilization and metabolism, though the clinical significance of these mechanistic differences requires further study