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In plants, GAD is activated by abiotic stress (hypoxia, heat, cold, drought, and mechanical wounding) or biotic stress (predation and infection-induced wounding) to accumulate GABA 29

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Consistently, mitochondrial function is impeded in the skeletal muscle of SLD chickens and GHR knockdown cells, indicating that GHR promotes mitochondrial function in vivo and in vitro (Hu et al., 2019)